Table 2 AUC and the cutoff value of diagnostic indicators at the maximum of Youden index for GC metastases (N = 1667).

From: Predictive value of neutrophil-to-lymphocyte ratio for distant metastasis in gastric cancer patients

 

AUC

95% CI

Cut-off

Sen

Spe

Youden index

PPV

NPV

P value

NLR

0.679

0.653–0.705

2.91

0.55

0.734

0.284

0.549

0.734

 < 0.001

CEA

0.647

0.62–0.674

4.34

0.485

0.763

0.248

0.546

0.719

 < 0.001

CA199

0.649

0.622–0.675

18.69

0.497

0.741

0.238

0.537

0.727

 < 0.001

CA724

0.662

0.636–0.688

6.96

0.447

0.807

0.254

0.447

0.799

 < 0.001

P1

0.716

0.691–0.74

0.39

0.538

0.75

0.333

0.568

0.758

0.209

P2

0.73

0.705–0.754

0.39

0.649

0.728

0.377

0.637

0.733

Ref

  1. AUC area under receiver operating characteristics, CI confidence interval, Sen sensitivity, Spe specificity, PPV positive predictive value, NPV negative predictive value, P P value for comparison of AUC of reference with other indicators using DeLong’s test, P1 prediction probability obtained by binary logistic regression combining CEA, CA199, CA724, P2 prediction probability obtained by binary logistic regression combining CEA, CA199, CA724 and NLR, Ref reference.
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