Table 3 Prophylactic activities of leaf extract and fractions of S. officinarum.

From: In vitro and in vivo antimalarial activity and chemical profiling of sugarcane leaves

Treatment

Dose (mg/kg)

Parasitaemia

Chemosuppression (%)

Mean survival time (MST) (day)

Control

–

18.8 ± 1.2

–

10.3 ± 0.3

Crude extract

170

15.5 ± 1.6b

17.8

11.7 ± 0.3

340

15.1 ± 1.2b

19.6

12.7 ± 0.7

510

15.2 ± 2.1b

19.3

12.7 ± 0.7

n-Hexane fraction

340

14.6 ± 1.3c

22.3

13.3 ± 1.9

DCM fraction

340

14.1 ± 2.1c

25.1

14.0 ± 1.0

Ethyl acetate fraction

340

13.0 ± 0.8c

31.0

15.3 ± 0.3

n-Butanol fraction

340

11.5 ± 1.3c

39.2

17.0 ± 1.0a

Pyrimethamine

1.2

2.2 ± 1.0c

88.6

25.0 ± 0.3c

  1. Values are expressed as mean ± SEM. Significance relative to control. ap < 0.05; bp < 0.01; cp < 0.001 (n = 6).
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