Table 4 Mean survival time of mice treated with leaf extract and fractions of S. officinarum during established P. berghei infection in mice.

From: In vitro and in vivo antimalarial activity and chemical profiling of sugarcane leaves

Treatment

Dose (mg/kg)

Mean survival time (days)

% Parasitaemia on D7

Chemosuppression (%)

Control

–

12.5 ± 0.3

31.7 ± 2.4

–

Crude extract

170

18.3 ± 0.8b

14.5 ± 1.6c

54.1

340

19.5 ± 1.0c

13.7 ± 1.3c

56.8

510

21.3 ± 1.5c

11.5 ± 2.78 c

63.9

n-Hexane fraction

340

19.8 ± 0.8c

15.0 ± 1.86b

52.6

DCM fraction

340

20.8 ± 0.8c

12.2 ± 1.3c

61.5

Ethyl acetate fraction

340

20.0 ± 0.0c

12.5 ± 0.9c

60.7

n-Butanol fraction

340

23.0 ± 1.1c

10.5 ± 2.4c

66.9

Chloroquine

5

28.5 ± 1.2c

1.1 ± 0.9c

96.7

  1. Values are expressed as mean ± SEM. Significance relative to control. ap < 0.05; bp < 0.01; cp < 0.001. n = 6.
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