Table 1 Descriptive statistics of the study population with data on germline variants based on genome-wide association study and somatic mutations based on targeted tumor sequencing (n = 1375 colorectal cancer cases).
From: Association between germline variants and somatic mutations in colorectal cancer
Hypermutated (N = 241) | Not Hypermutated (N = 1134) | Overall (N = 1375) | |
|---|---|---|---|
Sex | |||
Female | 141 (59%) | 558 (49%) | 699 (51%) |
Male | 100 (41%) | 576 (51%) | 676 (49%) |
Age at diagnosis | |||
Mean (SD) | 64.0 (12.5) | 61.0 (12.0) | 61.6 (12.2) |
Median [Min, Max] | 66.0 [28.0, 90.0] | 63.0 [21.0, 91.0] | 63.0 [21.0, 91.0] |
Study | |||
CORSA | 22 (9%) | 84 (7%) | 106 (8%) |
CPSII | 54 (22%) | 164 (14%) | 218 (16%) |
OFCCR | 91 (38%) | 546 (48%) | 637 (46%) |
SFCCR | 74 (31%) | 340 (30%) | 414 (30%) |
Number non silent indel mutations | |||
Mean (SD) | 14.7 (11.3) | 1.01 (1.40) | 3.40 (7.14) |
Median [Min, Max] | 13.0 [0, 49.0] | 1.00 [0, 14.0] | 1.00 [0, 49.0] |
Number non silent SNV mutations | |||
Mean (SD) | 36.5 (39.0) | 4.72 (2.45) | 10.3 (20.4) |
Median [Min, Max] | 26.0 [2.00, 334] | 5.00 [0, 14.0] | 5.00 [0, 334] |
Number non silent indel and SNV Mutations | |||
Mean (SD) | 51.2 (39.0) | 5.73 (3.03) | 13.7 (23.9) |
Median [Min, Max] | 44.0 [2.00, 335] | 5.00 [0, 24.0] | 6.00 [0, 335] |
