Table 1 Top ten most abundant peptidases identified in F. hepatica eggs at different points of development.

From: Transcriptomic and proteomic profiling of peptidase expression in Fasciola hepatica eggs developing at host’s body temperature

 

Transcriptomics data

Proteomics data

#

Peptidase ID

Family

TPM

#

Peptidase

Family

PPM

T0

33

Cathepsin D

A01

3846.41

22

Ubiquitin carboxyl terminal hydrolase

C12

7866.39

121

Cathepsin L (CL0)

C01

1157.89

135

Cathepsin D

A01

1047.99

332

Signalase subunit

S26

413.73

156

Cathepsin L (CL1_3b)

C01

900.96

463

Furin

S08

265.74

261

Proteasome subunit α_2

T01

378.09

465

Ubiquitin carboxyl terminal hydrolase

C12

265.14

293

Proteasome subunit α_1

T01

290.42

473

Signalase 2A

A22

255.07

314

Secreted cathepsin L1 (CL1_3a)

C01

242.53

513

Cercarial peptidase

S01

227.85

316

Cathepsin L (CL0)

C01

240.05

537

Peptidase S1 domain containing protein

S01

213.41

344

Calpain-2 catalytic subunit

C02

201.18

553

Cathepsin B (CB9)

C01

202.27

345

Secreted cathepsin L2 (CL2)

C01

198.09

578

Secreted cathepsin L (CL1_3a)

C01

191.84

353

Proteasome subunit β_1

T01

190.49

T5

33

Cathepsin D

A01

3387.20

18

Ubiquitin carboxyl terminal hydrolase

C12

8634.68

161

Cathepsin L (CL0)

C01

963.85

125

Cathepsin D

A01

1288.93

267

Cathepsin B (CB9)

C01

585.06

254

Proteasome subunit α_2

T01

393.11

400

Signalase subunit

S26

370.72

291

Proteasome subunit α_3

T01

306.41

486

Proteasome subunit β_1

T01

282.88

314

Proteasome prosome macropain subunit β

T01

262.86

539

Ubiquitin carboxyl terminal hydrolase

C12

247.31

321

Cathepsin L (CL0)

C01

256.38

552

Mov34/MPN/PAD-1 family protein

M67

239.47

331

Proteasome subunit α_4

T01

230.80

567

Furin_1

S08

232.23

337

Cathepsin L (CL1_3b)

C01

223.67

597

Proteasome subunit α_1

T01

218.11

342

Proteasome subunit β_1

T01

216.57

613

Putative signalase

A22

209.55

361

Cytochrome b-c1 subunit 1

M16

197.33

T10

62

Cathepsin D

A01

2406.63

24

Ubiquitin carboxyl terminal hydrolase

C12

7602.25

232

Cathepsin L (CL0)

C01

712.57

91

Cathepsin D

A01

1441.69

371

Signalase subunit

S26

449.44

139

Cathepsin L (CL1_3b)

C01

916.26

378

Cathepsin B (CB9)

C01

438.60

212

Proteasome subunit α_1

T01

468.51

456

Proteasome subunit β_1

T01

349.47

223

Proteasome subunit α_2

T01

416.09

464

Mov34/MPN/PAD-1 family protein

M67

342.65

260

Proteasome prosome macropain subunit β

T01

289.92

531

Proteasome subunit β_2

T01

290.20

269

Cathepsin L (CL0)

C01

271.49

569

Proteasome subunit β_3

T01

271.71

282

Secreted cathepsin L2 (CL2)

C01

252.02

579

Proteasome subunit α_1

T01

266.31

286

Proteasome subunit β_1

T01

247.40

690

Proteasome subunit β_4

T01

216.17

302

Proteasome subunit α_4

T01

220.22

  1. The ranking of peptidases relative to the abundance of all quantified proteins is shown in column #. Peptidases quantified by both methods (RNA-seq and LC–MS/MS) at a given time point are highlighted in bold. Cathepsin L0, L1, and cathepsin B9 isoforms (bold italics) were named according to Cwiklinski et al.50 nomenclature.
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