Table 1 Characteristics of the cargoes selected for MTD conjugation.
From: Efficient transdermal delivery of functional protein cargoes by a hydrophobic peptide MTD 1067
Cargo | Gene and peptide accession numbers | Molecular weight, Da | Functional structure | Biological activity | Refs. |
|---|---|---|---|---|---|
Growth hormone-releasing peptide-6 (GHRP-6) | Pubchem SID: 135,652,165 PubChem CID: 4,345,065 | 873 | Peptide | Antagonist of α-MSH Collagen synthesis | |
MTD-GHRP-6 | Synthetic peptide | 1898 | |||
Truncated form of insulin-like growth factor-I (des(1-3)IGF-I) | BankIt2569064 Des (1-3)IGF-I ON156849 | 7785 | Monomeric protein | Cell growth and maintenance Hair growth | |
MTD-des(1-3)IGF-I | BankIt2569065 MTD-des(1-3)IGF-I ON156850 | 8564 | |||
Platelet-derived growth factor (PDGF) BB | BankIt2569068 PDGFB ON156851 | 24,851 | Dimeric protein | Cell growth and division Production of matrix proteins | |
MTD-PDGF-BB | BankIt2569071 MTD-PDGFB ON156852 | 26,671 |
