Table 3 The differences of parameters between patients of MSA-C and SCA with different disease durations.

From: Radiological hints for differentiation of cerebellar multiple system atrophy from spinocerebellar ataxia

The differences of parameters between patients with MSA-C and SCA with a disease duration within 1 year

  

Total (N = 132)

SCA (N = 47)

MSA-C (N = 85)

p value

HCBSb

Positive

 

1 (2.13%)

70 (82.35%)

0.000

Negative

 

46 (97.87%)

15 (17.65%)

 

Disease durationa

 

0.91 ± 0.28

0.87 ± 0.34

0.94 ± 0.24

0.264

Cerebelluma

NAA/Cr

0.76 ± 0.18

0.94 ± 0.14

0.66 ± 0.12

0.000

Cho/Cr

0.65 ± 0.15

0.74 ± 0.17

0.60 ± 0.10

0.000

Vermisa

NAA/Cr

0.78 ± 0.10

0.86 ± 0.09

0.73 ± 0.08

0.000

Cho/Cr

0.64 ± 0.09

0.69 ± 0.09

0.61 ± 0.07

0.000

SARA scorea

 

Total (N = 111)

SCA (N = 42)

MSA-C (N = 69)

0.000

 

9.48 ± 5.32

6.40 ± 4.22

11.19 ± 5.11

 

The differences of parameters between patients with MSA-C and SCA with a disease duration in the bracket of 2–3 years

  

Total (N = 191)

SCA (N = 89)

MSA-C (N = 102)

 

HCBSb

Positive

 

8 (8.99%)

95 (93.14%)

0.000

Negative

 

81 (91.01%)

7 (6.86%)

 

Disease durationa

 

2.51 ± 0.50

2.57 ± 0.50

2.46 ± 0.50

0.120

Cerebelluma

NAA/Cr

0.76 ± 0.19

0.88 ± 0.19

0.65 ± 0.11

0.000

Cho/Cr

0.64 ± 0.13

0.70 ± 0.13

0.59 ± 0.10

0.000

Vermisa

NAA/Cr

0.75 ± 0.11

0.81 ± 0.11

0.73 ± 0.08

0.000

Cho/Cr

0.64 ± 0.10

0.69 ± 0.10

0.60 ± 0.08

0.000

SARA scorea

 

Total (N = 163)

SCA (N = 76)

MSA-C (N = 87)

0.000

 

11.86 ± 6.47

8.49 ± 5.70

14.76 ± 5.66

 

The differences of parameters between patients with MSA-C and SCA with a disease duration in the bracket of 4–5 years

  

Total (N = 160)

SCA (N = 61)

MSA-C (N = 99)

 

HCBSb

Positive

 

3 (4.92%)

96 (96.97%)

0.000

Negative

 

58 (95.08%)

3 (3.03%)

 

Disease durationa

 

4.49 ± 0.51

4.62 ± 0.49

4.41 ± 0.50

0.009

Cerebelluma

NAA/Cr

0.69 ± 0.1863 + 

0.85 ± 0.15

0.59 ± 0.11

0.000

Cho/Cr

0.60 ± 0.14

0.68 ± 0.11

0.54 ± 0.13

0.000

Vermisa

NAA/Cr

0.71 ± 0.13

0.82 ± 0.09

0.64 ± 0.10

0.000

Cho/Cr

0.61 ± 0.11

0.69 ± 0.08

0.57 ± 0.09

0.000

SARA scorea

 

Total (N = 134)

SCA (N = 53)

MSA-C (N = 81)

0.000

 

16.43 ± 7.06

11.61 ± 4.07

19.52 ± 6.84

 

The differences of parameters between patients with MSA-C and SCA with a disease duration in the bracket of 6–8 years

  

Total (N = 151)

SCA (N = 88)

MSA-C (N = 63)

 

HCBSb

Positive

 

11 (12.50%)

61 (96.83%)

0.000

Negative

 

77 (87.50%)

2 (3.17%)

 

Disease durationa

 

6.77 ± 0.78

6.69 ± 0.76

6.87 ± 0.81

0.159

Cerebelluma

NAA/Cr

0.72 ± 0.21

0.83 ± 0.18

0.56 ± 0.13

0.000

Cho/Cr

0.60 ± 0.15

0.68 ± 0.11

0.48 ± 0.11

0.000

Vermisa

NAA/Cr

0.73 ± 0.13

0.81 ± 0.09

0.62 ± 0.09

0.000

Cho/Cr

0.61 ± 0.13

0.68 ± 0.10

0.52 ± 0.10

0.000

SARA scorea

 

Total (N = 132)

SCA (N = 80)

MSA-C (N = 52)

0.000

 

16.50 ± 8.44

11.99 ± 5.50

22.99 ± 7.70

 

The differences of parameters between patients with MSA-C and SCA with a disease duration longer than 8 years

  

Total (N = 157)

SCA (N = 127)

MSA-C (N = 30)

 

HCBSb

Positive

 

13 (10.24%)

29 (96.67%)

0.000

Negative

 

114 (89.76%)

1 (3.33%)

 

Disease durationa

 

12.50 ± 4.94

13.24 ± 5.17

9.38 ± 1.60

0.000

Cerebelluma

NAA/Cr

0.74 ± 0.17

0.78 ± 0.15

0.54 ± 0.12

0.000

Cho/Cr

0.62 ± 0.13

0.65 ± 0.11

0.47 ± 0.11

0.000

Vermisa

NAA/Cr

0.74 ± 0.14

0.76 ± 0.13

0.63 ± 0.10

0.000

Cho/Cr

0.62 ± 0.11

0.65 ± 0.10

0.52 ± 0.09

0.000

SARA scorea

 

Total (N = 128)

SCA (N = 103)

MSA-C (N = 25)

0.000

 

17.96 ± 8.95

16.20 ± 8.25

25.20 ± 8.20

 
  1. aMann-Whitney test. bChi-square test.
  2. Numeric data are presented as mean ± standard deviation.
  3. HCBS hot cross bun sign; MSA-C multiple system atrophy, cerebellar type; SCA spinocerebellar ataxia; SARA Scale for the Assessment and Rating of Ataxia; NAA N-acetyl aspartate; Cr creatinine; Cho Choline.
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