Table 7 Change in diagnosis following MRI and 18F-Flutemetamol PET.
Syndromal diagnosis at interim analysis | Change post-MRI and 18F-Flutemetamol PET in syndromal group, No. (%) | Comparing to priori threshold (30%), p value | |||
|---|---|---|---|---|---|
(A) | |||||
SCD (n = 5) | 0 | / | |||
MCI (n = 35) | 32, 78% | p < 0.0001 | |||
Dementia (n = 44) | 23, 61% | p < 0.0001 | |||
Total | 55, 65% | p < 0.0001 | |||
Etiological diagnosis at interim analysis | Change post-MRI and 18F-Flutemetamol PET findings in etiological subgroup, No., % | Comparing to priori threshold (30%), p value | Amyloid status post-neuroimaging | No. of subjects in each amyloid status | Diagnosis post-neuroimaging of changed subjects |
|---|---|---|---|---|---|
(B) | |||||
SCD (n = 5) | 0 | / | Positive | / | / |
Negative | |||||
AD-related MCI (n = 19) | 12, 63% | p < 0.01 | Positive | 3 | 7 Non-AD related MCI, 3 AD-related Dementia, 2 Non-AD related Dementia |
Negative | 9 | ||||
Non-AD related MCI (n = 9) | 7, 78% | p < 0.01 | Positive | 5 | 2 SCD, 1 AD-related MCI, 1 Non-AD related Dementia, 3 AD-related Dementia |
Negative | 2 | ||||
Non-specific MCI (n = 13) | 13, 100% | p < 0.0001 | Positive | 7 | 2 AD-related MCI, 8 Non-AD related MCI, 3 AD-related Dementia |
Negative | 6 | ||||
AD-related Dementia (n = 24) | 13, 54% | p < 0.025 | Positive | 1 | 1 AD-related MCI, 4 Non-AD related MCI, 8 Non-AD related Dementia |
Negative | 12 | ||||
Non-AD related Dementia (n = 6) | 2, 23% | p > 0.025 | Positive | 1 | 2 AD-related Dementia |
Negative | 1 | ||||
Non-specific Dementia (n = 8) | 8, 100% | p < 0.0001 | Positive | 6 | 1 SCD, 6 AD-related Dementia, 2 Non-AD related Dementia |
Negative | 2 | ||||
