Figure 5 | Scientific Reports

Figure 5

From: Towards a general approach for tailoring the hydrophobic binding site of phenylalanine ammonia-lyases

Figure 5

Active orientations of 4-(trifluoromethyl) cinnamic acid 2j within (A) wt-RtPAL (green, − 5.5 kcal/mol), H137V RtPAL (indigo, − 6.9 kcal/mol), H137V/Q138L RtPAL (grey, − 7.5 kcal/mol), and I472V RtPAL (purple, − 5.5 kcal/mol) and (B) wt-PcPAL (green, − 4.8 kcal/mol), F137V PcPAL (grey, − 8.9 kcal/mol), and I460V PcPAL (purple, − 6.4 kcal/mol). The modified residues and the active site orientation of 2j within the corresponding variant is marked with similar colour.

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