Table 3 Top 10 upregulated and down regulated metabolites in low-fertility bulls.
S. no. | ID | Metabolite | Log2 (fold change) | Metabolism |
|---|---|---|---|---|
Top 10 upregulated metabolites | ||||
1. | HMDB0000965 | Hypotaurine | 6.2286 | Taurine and hypotaurine metabolism |
2. | HMDB0004122 | Selenocystine | 3.5978 | Selenium metabolism |
3. | HMDB0003537 | DITP | 3.2176 | Purine metabolism |
4. | HMDB0000156 | l-malic acid | 3.1025 | Citrate cycle (TCA cycle), Pyruvate metabolism, Glyoxylate and dicarboxylate metabolism |
5. | HMDB0001191 | Deoxyuridine triphosphate | 2.4029 | Pyrimidine metabolism |
6. | HMDB0001096 | Carbamoyl phosphate | 2.2636 | Nitrogen metabolism, Arginine biosynthesis, Alanine, aspartate and glutamate metabolism |
7. | HMDB0012238 | Iodide | 2.0618 | Thyroxine metabolism |
8. | HMDB0001011 | Methacrylyl-CoA | 2.0549 | Valine, leucine and isoleucine degradation |
9. | HMDB0033458 | N-carbamoylputrescine | 1.9252 | Arginine and proline metabolism |
10. | HMDB0003369 | CDP-alpha-d-Glucose | 1.6811 | Starch and sucrose metabolism, amino sugar and nucleotide sugar metabolism |
Top 10 down regulated metabolites | ||||
1. | HMDB0001021 | Malyl-CoA |  − 0.98359 | Glyoxylate and dicarboxylate metabolism, Methane metabolism |
2. | HMDB0011104 | 3-Phosphoadenylylselenate |  − 1.0946 | Selenoamino acid metabolism |
3. | HMDB0034259 | 3-Nitropropanoic acid |  − 1.1658 | Beta-Alanine metabolism |
4. | HMDB0001142 | FMNH2 |  − 1.5893 | Riboflavin metabolism, Biosynthesis of cofactors |
5. | HMDB0001484 | Acetoacetyl-CoA |  − 1.811 | Synthesis and degradation of ketone bodies Butanoate metabolism, Terpenoid backbone biosynthesis, Pyruvate metabolism, Propanoate metabolism |
6. | HMDB0003419 | Formyl-CoA |  − 2.0431 | Glyoxylate and dicarboxylate metabolism |
7. | HMDB0000652 | Chondroitin 4-sulfate |  − 2.3791 | Glycosaminoglycan degradation |
8. | HMDB0002346 | Lactyl-CoA |  − 3.3451 | Propanoate metabolism |
9. | HMDB0002127 | 3-Mercaptolactic acid |  − 3.479 | Cysteine and methionine metabolism |
10. | HMDB0003417 | d-cysteine |  − 4.8072 | Cysteine and methionine metabolism |
