Figure 5 | Scientific Reports

Figure 5

From: Deeper insights into long-term survival heterogeneity of pancreatic ductal adenocarcinoma (PDAC) patients using integrative individual- and group-level transcriptome network analyses

Figure 5

Genomic distributions of differentially expressed genes (DEGs) and PEEPs related to PDAC survivors using Circos plots and functional profiles of perturbation data: (A) first (grey) and second outermost circle labeled with numbers represent chromosomes (multiple colors); the third outermost track represents DEGs (red and green indicating, respectively up-regulated and down-regulated DEGs as scattered points); the fourth outermost circle represents genomic locations of genes associated with survival (purple lines); the nine innermost circles (highlighted in orange) refer to the z-score for each LT survivor (ranging from LT1 to LT9); (B) Enriched KEGG pathways (P1 to P19 (out of 196)) shown via Circos Table Viewer. Each link refers to an LT survivor and a significantly enriched pathway (adjusted p-value < 0.05) based on the perturbed gene set found in that individual (data for LT2, LT7 and LT9 are shown). Uniquely enriched pathways across LT survivors are given in Table S2.

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