Table 2 Time trend changes of blood-based biomarkers in patients with septic shock according to survivor and non-survivor groups.

From: Comparison of lactate/albumin ratio to lactate and lactate clearance for predicting outcomes in patients with septic shock admitted to intensive care unit: an observational study

Groups

Time trends

Time interaction

Time * group interaction

Baseline

6 h

12 h

24 h

Unadjusted (P value)b

Adjusted (P value)c

Unadjusted (P value)d

Adjusted (P value)e

Lactate/albumin

       

Survivors

0.149 ± 0.036

–

–

–

–

–

–

–

Non-survivors

0.259 ± 0.053

–

–

–

–

–

–

–

P valuea

< 0.001*

       

Lactate

       

Survivors

3.94 ± 0.248

3.17 ± 0.267

2.58 ± 0.330

2.05 ± 0.299

< 0.001*

0.734

< 0.001*

< 0.001*

Non-survivors

3.93 ± 0.612

3.35 ± 0.546

3.05 ± 0.559

2.82 ± 0.480

    

P valuea

0.897

0.010*

< 0.001*

< 0.001*

    

Lactate clearance

       

Survivors

–

19.39 ± 6.14

34.43 ± 8.08

47.87 ± 7.89

< 0.001*

0.327

< 0.001*

< 0.001*

Non-survivors

–

15.05 ± 5.92

22.14 ± 9.42

27.61 ± 7.75

    

P valuea

 

< 0.001*

< 0.001*

< 0.001*

    
  1. *P < 0.05 considered as significant.
  2. aP value based on t-test between groups.
  3. bUnadjusted P value based on time interaction in repeated measures ANOVA.
  4. cAdjusted P value (adjusting for age, gender, comorbidities, SOFA and APACHE IV) based on time interaction in repeated measures ANOVA.
  5. dUnadjusted P value based on time * group interaction in repeated measures ANOVA.
  6. eAdjusted P value (adjusting for age, gender, comorbidities, SOFA and APACHE IV) based on time * group interaction in repeated measures ANOVA.
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