Table 2 Differentially expressed proteins in mild COVID-19 (n = 5) compared with healthy individuals (n = 10).

From: Saliva changes in composition associated to COVID-19: a preliminary study

Accession (UniProt)

Protein name

Max. no. of quantified peptides

Molecular function

K-W test (P-value)

Dunn’ test for multiple comparison

Regulation in COVID-19 mild disease

Log2 fold change

P-value

P30838

Aldehyde dehydrogenase, dimeric NADP-preferring

2

3-chloroallyl aldehyde dehydrogenase activity

0.01*

−1.29

0.006**

Down

Q8N4F0

BPI fold-containing family B member 2

5

Lipid binding

0.003**

−1.19

0.01*

Down

P29508

Serpin B3

5

Serine-type endopeptidase inhibitor activity

0.01*

−1.08

0.01*

Down

P12273

Prolactin-inducible protein

2

Actin binding

0.04*

−0.72

0.01*

Down

P04792

Heat shock protein beta-1

2

Protein kinase C binding

0.04*

1.21

0.04*

Up

P09525

Annexin A4

3

Calcium ion binding

0.01*

1.00

0.006**

Up

Q13510

Acid ceramidase

2

Hydrolase activity

0.02*

0.90

0.01*

Up

P52907

F-actin-capping protein subunit alpha-1

2

Actin binding

0.04*

0.79

0.01*

Up

P01619

Immunoglobulin kappa variable 3–20

2

Antigen binding

0.02*

0.72

0.009**

Up

P0C0L4

Complement C4-A

6

Endopeptidase inhibitor activity

0.04*

0.71

0.01*

Up

  1. K-W: Kruskal–Wallis.
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