Table 3 Differentially expressed proteins in severe COVID-19 (n = 5) compared with healthy individuals (n = 10).
From: Saliva changes in composition associated to COVID-19: a preliminary study
Accession (UniProt) | Protein name | Max. no. of quantified peptides | Molecular function | K-W test (P-value) | Dunn’ test for multiple comparison | Regulation in COVID-19 mild disease | |
|---|---|---|---|---|---|---|---|
Log2 fold change | P-value | ||||||
P01036 | Cystatin-S | 6 | Cystein-type endopetidase inhibitor activity | 0.002** | −2.54 | 0.001** | Down |
Q6P5S2 | Protein LEG1 homolog | 5 | 0.02* | −2.32 | 0.006** | Down | |
P01034 | Cystatin-C | 2 | Peptidase inhibitor activity | 0.005** | −1.78 | 0.002** | Down |
P23280 | Carbonic anhydrase 6 | 5 | Zinc ion binding | 0.01* | −1.78 | 0.007** | Down |
P09228 | Cystatin-SA | 5 | Cystein-type endopetidase inhibitor activity | 0.008** | −1.61 | 0.002** | Down |
P01037 | Cystatin-SN | 5 | Cystein-type endopetidase inhibitor activity | 0.004** | −1.57 | 0.001** | Down |
Q8N4F0 | BPI fold-containing family B member 2 | 5 | Lipid binding | 0.003** | −1.43 | 0.003** | Down |
P0DUB6 | Alpha-amylase 1A | 3 | Calcium ion binding | 0.009** | −1.40 | 0.003** | Down |
P29401 | Transketolase | 4 | Calcium ion binding | 0.04* | −1.37 | 0.02* | Down |
Q96DA0 | Zymogen granule protein 16 homolog B | 3 | Carbohydrate binding | 0.04* | −1.05 | 0.01* | Down |
P29508 | Serpin B3 | 5 | Serine-type endopeptidase inhibitor activity | 0.01* | −1.00 | 0.02* | Down |
P26038 | Moesin | 4 | Cell adhesion molecule binding | 0.02* | −0.85 | 0.008** | Down |
P60709 | Actin cytoplasmatic 1 | 6 | ATP binding | 0.03* | −0.68 | 0.01* | Down |
P02675 | Fibrinogen beta chain | 5 | Structural molecule activity | 0.04* | 1.02 | 0.01* | Up |
Q43707 | Apha-actinin-4 | 10 | Calcium ion binding | 0.01* | 0.73 | 0.005** | Up |
