Scientific Reports

Table 3 Synthesis of 2‐amino‐4H‐chromene derivatives using creatine-based catalyst.

From: Functionalization of magnetic nanoparticles by creatine as a novel and efficient catalyst for the green synthesis of 2-amino-4H-chromene derivatives


Entry	Aldehyde	Product	Time (min)	Yield^a (%)	Mp (°C)
Entry	Aldehyde	Product	Time (min)	Yield^a (%)	Observed	Literature
1	4-nitrobenzaldehyde	4a	5	96	176–182	176–183⁵⁶
2	3-nitrobenzaldehyde	4b	4	96	204–207	204–206⁵⁷
3	2-chlorobenzaldehyde	4c	4	96	212–215	213–215^58,59
4	3-chlorobenzaldehyde	4d	7	92	228–232	229–232⁶⁰
5	4-chlorobenzaldehyde	4e	6	94	214–217	214–216⁵⁹
6	3-methylbenzaldehyde	4f	10	88	197–200	198–200⁶¹
7	4-methylbenzaldehyde	4g	10	86	215–219	215–218⁶²
8	4-isopropylbenzaldehyde	4h	12	91	196–200	198–200⁶¹
9	2-methoxybenzaldehyde	4i	12	84	202–204	203–207⁵⁶
10	3-methoxybenzaldehyde	4j	8	86	197–200	197–199⁶³
11	4-methoxybenzaldehyde	4k	10	86	194–197	194–196^64,65,66
12	3,4,5-trimethoxybenzaldehyde	4l	9	91	175–177	175–179⁶⁷
13	3-hydroxybenzaldehyde	4m	15	82	233–235	232–234⁶⁸
14	4-hydroxybenzaldehyde	4n	18	81	208–210	208–210⁶⁹
15	2,4-dichlorobenzaldehyde	4o	6	94	118–120	118–120⁷⁰

^aIsolated yields.

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