Table 1 Demographics, epidemiological, and clinical features of patients with sepsis, evaluated for possible diagnosis of sepsis-associated encephalopathy.

From: Clinical features, electroencephalogram, and biomarkers in pediatric sepsis-associated encephalopathy

Characteristic

Total, no. (%)

Total

33 (100)

Age, years, median (IQR)

1 (1–2)

Infants (< 12 m)

8 (24.2)

Toddler (≥ 12 m, < 3 years)

20 (60.6)

Preschool (≥ 3 y, < 5 years)

1 (3.0)

Grade-schooler (≥ 5 years, < 12 years)

3 (9.1)

Teen (≥ 12 years, < 18 years)

1 (3.0)

Sex, n (%)

Male

12 (36.4)

Female

21 (63.6)

Race, n (%)

White

17 (51.5)

Black

16 (48.5)

Bodyweight, kg, median (IQR)

11 (9–13.5)

Type of admission

Clinical

31 (100)

Surgical

Source of infection, n (%)

Respiratory (pneumonia)

26 (78.8)

Dermatology (cellulitis)

3 (9.1)

Gastrointestinal (gastroenteritis)

2 (6.1)

Urinary

2 (6.1)

Comorbidities, n (%)

7 (21.2)

Asthma

5 (15.2)

Congenital heart defect

1 (3.0)

Mucocutaneous disease

1 (3.0)

Sepsis diagnosis criteriaa n (%)

Heart rate (tachycardia)

33 (100)

Respiratory rate (tachypnea)

33 (100)

Temperature (fever)

25 (75.8)

Increased leucocyte number

27 (81.8)

Organ dysfunction at diagnosisa n (%)

33 (100)

Cardiovascular

33 (100)

Respiratory

25 (75.8)

Neurologicalb

4 (12.1)

PELOD 2 (organ dysfunction)

Admission score, median (IQR)

3 (2–5)

No. of organ dysfunctions, median (IQR)

1 (1–2)

PIM3, median (IQR), % death probability

4.6 (1.5–6.0)

Length of stay in PICU, median (IQR)

16 (11–23)

Outcome

Discharge

32 (97)

Death

1 (3)

  1. IQR interquartile range, PELOD 2 Pediatric Logistic Dysfunction 2, PIM3 Pediatric Index of Mortality 3.
  2. aGoldstein et al.35.
  3. bThe international consensus criteria for neurological dysfunction consider a Glasgow Coma Score ≤ 11, different from the one adopted in this study (< 15) to diagnose sepsis-associated encephalopathy.