Figure 4
Female Cln1−/− mice exhibit more, and earlier, seizures, compared to males. (a) While the four longest-lived mice were all male, there was no difference in life span between untreated, EEG-monitored males (n = 9) and females (n = 11). (b) Females exhibited more total seizures, over the period when all animals remained alive, compared to males, and they appeared to have an earlier onset. (c,d) A higher percentage of female mice exhibited at least 1 seizure earlier compared to males, and more females exhibited seizures across this timeframe than males as measured by area under the curve. Data shown are means ± SEM. *Indicates p = 0.038; **indicates p < 0.0025.
