Figure 3
Effect of C-DIM12 on gene expression of pro-inflammatory cytokines and chemokines after ICH. C-DIM12 (50 mg/kg) or vehicle was orally administered at 3 h after ICH induction. Expression levels of IL-6 (a), IL-15 (b), CCL2 (c) and CXCL2 (d) mRNAs were quantified at 6 h after ICH. Number of mice examined was 4 in sham group, 5 in ICH + vehicle group, and 5 in ICH + C-DIM12 group, respectively. *P < 0.05, **P < 0.01, ***P < 0.001 (ANOVA results: for a, F2,11 = 22.26, P < 0.001; for b, F2,11 = 14.07, P < 0.001; for c, F2,11 = 30.44, P < 0.001; for d, F2,11 = 6.360, P = 0.015).
