Figure 7
From: The close interaction between hypoxia-related proteins and metastasis in pancarcinomas
Integration of multi-omics approaches and functional enrichment analysis. (A) Venn diagram shows 30 hypoxic/metastatic/angiogenic proteins significantly expressed in the PCA-TCGA, the protein–protein interactome network, and the shortest paths to cancer hallmark phenotypes (metastasis and angiogenesis). (B) Circos plot showing that several hypoxia-related proteins promote or suppress cancer hallmark phenotypes. (C) Manhattan plot of the functional enrichment analysis showing the most significant GO: biological processes related to hypoxia and cell migration, and the most significant signaling pathways with a Benjamini–Hochberg FDR q < 0.001. FDR: false discovery rate; GO: gene ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes.
