Table 5 Comparison of PCV, ED, Fuzzy integral based method and three alignment-based methods ClustalW, Clustal Omega, and Muscle based on AUC values for 12 benchmark datasets.

From: An accurate alignment-free protein sequence comparator based on physicochemical properties of amino acids

Dataset/method

PCV

FI5

FI5 (based on our classification matrices)

ED34

ClustalW

Muscle

Clustal Omega

ND5

0.9636

0.97

0.9124

0.9312

0.9636

0.9636

0.9636

ND6

0.9549

0.98

0.9180

0.9549

0.9549

0.9549

0.9549

TF

0.9242

0.85

0.9481

0.9262

0.9294

0.9294

0.9294

Coronavirus (24)

0.9631

–

–

–

0.9945

0.8711

0.8884

Coronavirus (50)

0.9549

0.96

0.9929

–

0.9620

0.9620

0.9620

AFP

0.7892

–

–

–

0.9536

0.9581

0.9431

Beta globin (9)

0.9646

–

–

0.9646

0.9646

0.9646

0.9646

Beta globin (50)

0.9468

0.91

0.9009

–

0.9398

0.9385

0.9385

Beta globin (88)

0.9672

–

–

–

0.9605

0.9608

0.9608

Xylanase

0.8086

0.89

0.8941

0.7894

0.9554

0.9643

0.9566

HRV

0.9997

–

–

–

0.9772

0.9997

0.9997

Influenza A

0.9939

–

–

–

0.9912

–

0.7034

  1. Significant values are in bold.
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