Table 3 Analysis of selected top 11 important variables in the study population.

From: Development of early prediction model for pregnancy-associated hypertension with graph-based semi-supervised learning

(a) In training set

Selected variables

Pregnancy-associated HTN (−) (n = 949)

Pregnancy-associated HTN ( +) (n = 22)

P-value

Variables before pregnancy

Maternal age

32.2 ± 3.9

33.3 ± 4.9

0.383

History of preeclampsia

7 (0.7%)

2 (9.1%)

0.016

Weight before pregnancy

57.9 ± 10.1

69.0 ± 13.9

 < 0.001

BMI before pregnancy

22.2 ± 3.6

26.2 ± 5.2

 < 0.001

Variables in the first trimester

Systolic BP in early pregnancy

113.3 ± 11.4

132.7 ± 17.2

 < 0.001

Diastolic BP in early pregnancy

67.3 ± 8.4

80.5 ± 10.8

 < 0.001

Systolic BP in late first trimester

112.6 ± 11.4

126.3 ± 14.4

 < 0.001

Diastolic BP in late first trimester

67.6 ± 8.6

77.9 ± 9.8

 < 0.001

Weight in late first trimester

58.8 ± 10.1

69.7 ± 14.0

 < 0.001

BMI in late first trimester

22.5 ± 3.6

26.4 ± 5.2

 < 0.001

Hemoglobin level in the first trimester

12.6 ± 1.0

13.6 ± 1.0

 < 0.001

(b) In test set

Selected variables

Pregnancy-associated HTN (−) (n = 365)

Pregnancy-associated HTN ( +) (n = 11)

P-value

Variables before pregnancy

Maternal age

32.4 ± 4.2

32.4 ± 4.3

0.891

History of preeclampsia

1 (0.3%)

2 (18.2%)

0.002

Weight before pregnancy

58.5 ± 10.9

65.1 ± 16.2

0.124

BMI before pregnancy

22.3 ± 3.8

25.5 ± 6.2

0.062

Variables in the first trimester

Systolic BP in early pregnancy

115.4 ± 11.1

130.5 ± 11.4

 < 0.001

Diastolic BP in early pregnancy

68.8 ± 8.4

79.1 ± 10.2

0.001

Systolic BP in late first trimester

114.4 ± 11.4

126.4 ± 10.1

0.001

Diastolic BP in late first trimester

68.5 ± 8.2

77.0 ± 11.8

0.011

Weight in late first trimester

59.3 ± 10.7

65.2 ± 16.5

0.169

BMI in late first trimester

22.6 ± 3.7

25.5 ± 6.1

0.089

Hemoglobin level in the first trimester

12.7 ± 1.0

13.2 ± 1.0

0.319

  1. Early pregnancy, measured at 7.7 ± 1.2 weeks; late first trimester, measured at 12.4 ± 0.5 weeks.
  2. BMI body mass index, BP blood pressure.