Figure 3

Chronic social defeat stress increased the amounts of brain lipid metabolites in stress-resilient mice. (a–e) The amounts of each metabolite in the prefrontal cortex (a), the nucleus accumbens (b), the dorsal striatum (c), the amygdala (d), and the hippocampus (e) in control mice, stress-susceptible mice, and stress-resilient mice. The lipid metabolites related to AA, EPA and DHA are shown on pink, yellow and beige backgrounds, respectively. The values were normalized to those in control mice. 15-HEPE in the prefrontal cortex was not detected (ND). The number of samples is shown below each bar. Values are expressed as means ± SEM. Tukey’s multiple comparisons test was used for statistical analyses. ^###P < 0.001 for the comparison between control and stress-susceptible mice, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 for the comparison between control and stress-resilient mice, and ^††P < 0.01, ^††††P < 0.0001 for the comparison between stress-susceptible mice and stress-resilient mice. See the text for abbreviations of lipid metabolites.