Table 1 Body weight and biochemical measurements at 20th week.

From: The effects of the voglibose on non-alcoholic fatty liver disease in mice model

 

Chow

HFHFr

HFHFr-V

HFHFr-P

Body weight (g)

27.0 ± 0.9

38.2 ± 3.4#

33.0 ± 2.8#†

35.0 ± 2.0#

Liver weight (g)

1.1 ± 0.1

3.0 ± 0.7#

1.8 ± 0.4#†

2.6 ± 0.4#*

Liver to body weight (%)

4.2 ± 0.1

7.9 ± 1.2#

5.3 ± 0.7#†

7.4 ± 0.8#*

AST (IU/L)

82.6 ± 17.4

463.8 ± 250.8#

154.2 ± 66.1

288.4 ± 96.8

ALT (IU/L)

26.0 ± 6.4

487.0 ± 303.1#

114.6 ± 88.8

255.6 ± 99.7

Fasting glucose (mg/dL)

133.6 ± 27.8

235.8 ± 118.4

177.0 ± 75.5

184.1 ± 31.8

Fasting insulin (ng/dL)

0.34 ± 0.02

0.25 ± 0.004#

0.25 ± 0.01#

0.26 ± 0.004#

HOMA-IR

2.8 ± 0.6

3.7 ± 1.9

2.4 ± 0.9

2.9 ± 0.5

  1. HFHFr, high-fat, high-fructose diet group; HFHFr-V, HFHFr diet with voglibose group; HFHFr-P, HFHFr diet with pioglitazone group; AST, aspartate aminotransferase; ALT, alanine aminotransferase; HOMA-IR, homeostasis model assessment of insulin resistance.
  2. #P < 0.05 vs. chow, P < 0.05 vs. HFHFr, *P < 0.05 vs. HFHFr-V.