Table 3 Adjusted odds ratios for cognitive impairment of subdomains in patients with de novo PD.

From: Associations of cognitive dysfunction with motor and non-motor symptoms in patients with de novo Parkinson’s disease

Subdomain

Variables

Odds ratio*

Confidence interval

P value

Adjusted P value$

Attention

UPDRS-III

n.a

n.a

n.a

n.a

HY stage

n.a

n.a

n.a

n.a

BDI

n.a

n.a

n.a

n.a

BAI

n.a

n.a

n.a

n.a

PFS

n.a

n.a

n.a

n.a

SCOPA-AUT

n.a

n.a

n.a

n.a

Language

UPDRS-III

1.0668

0.9905–1.1489

0.0877

0.3508

HY stage

4.7496

1.0074–22.3927

0.0489

0.1956

BDI

1.2680

0.6774–2.3738

0.4579

1.0000

BAI

1.0558

0.9646–1.1557

0.2387

0.9548

PFS

1.0053

0.9626–1.0499

0.8119

1.0000

SCOPA-AUT

1.0526

0.9687–1.1437

0.2262

0.9048

Memory

UPDRS-III

1.0687

1.0087–1.1322

0.0242

0.0968

HY stage

9.136

1.9618–42.3363

0.0048

0.0192

BDI

1.0916

1.0063 -1.1843

0.0349

0.1396

BAI

0.9971

0.9216–1.0788

0.9424

1.0000

PFS

1.0409

0.6271–1.7278

0.8767

1.0000

SCOPA-AUT

1.1726

1.0650–1.2711

0.0008

0.0032

Visuospatial

UPDRS-III

1.0970

1.0225–1.1770

0.0099

0.0396

HY stage

7.9772

1.4522–43.8207

0.0169

0.0676

BDI

1.0779

1.0005–1.1614

0.0486

0.1944

BAI

1.0736

0.9679–1.1908

0.1795

0.7180

PFS

1.0299

0.9901–1.0712

0.1426

0.5704

SCOPA-AUT

1.0654

0.99–1.1464

0.0906

0.3624

Executive

UPDRS-III

1.0651

1.0034–1.1306

0.0383

0.1532

HY stage

5.7182

1.281–25.5247

0.0223

0.0892

BDI

1.0924

1.0113–1.1801

0.0247

0.0988

BAI

1.0185

0.9283–1.1174

0.6988

1.0000

PFS

1.0484

1.0079–1.0905

0.0187

0.0748

SCOPA-AUT

1.1252

1.0383–1.2193

0.0040

0.0160

  1. *Odds ratio was obtained after adjusting for age, sex, and disease duration.
  2. $P-value adjustment with Bonferroni correction was conducted for multiple comparisons.
  3. PD, Parkinson’s disease; UPDRS-III, Unified Parkinson’s disease rating scale-part 3; BDI, Beck depression inventory; BAI, Beck anxiety inventory; PFS, Parkinson’s disease fatigue scale; SCOPA-AUT, the Scale for Outcomes in Parkinson’s disease-Autonomic questionnaire.
  4. Significant values are in bold.