Table 3 Results of the univariate analysis.
From: Presence of periodontitis may synergistically contribute to cancer progression via Treg and IL-6
IL-6 (pg/mL) | TGF-ß1 (ng/mL) | VEGF (pg/mL) | CCL22 (pg/mL) | Treg (%) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Median IQR | Median IQR | Median IQR | Median IQR | Median IQR | ||||||||||||
Sex | Female (21) | 1.4 | 1–3.4 | p = 0.95 | 18.3 | 15.15–24.4 | p = 0.095 | 229 | 143.5–418 | p = 0.80 | 643 | 506.5–727 | p = 0.56 | 3.15 | 2.15–3.795 | p = 0.83 |
Male (40) | 1.75 | 0.825–3.725 | 21.5 | 17.725–26.7 | 248 | 151–483.25 | 634 | 563–792 | 3.06 | 2.05–4.65 | ||||||
Diabetes mellitus | Presence (4) | 4.3 | 4.05–4.475 | p < 0.01 | 19.7 | 16.25–24.875 | p = 0.73 | 222 | 63–368.5 | p = 0.68 | 739.5 | 403.25–984.25 | p = 0.59 | 3.15 | 2.1–5.01 | p = 0.84 |
Absence (57) | 1.5 | 0.85–3 | 20.5 | 17.15–26.1 | 246 | 150–458.5 | 637 | 541.5–762.5 | 3.06 | 2.11–4.265 | ||||||
Cancer/ Periodontitis | C − P − (14) | 0.7* | 0.6–0.975 | p < 0.05 | 24.2 | 19.275–27.825 | NS | 250.5 | 169.75–314.75 | NS | 643 | 521.5–802.5 | NS | 3.15 | 2.515–4.265 | p < 0.05 |
C − P + (17) | 2.2 | 0.9–3.45 | 20.5 | 27–26.3 | 296 | 150.5–556.5 | 641 | 587–783 | 2.11† | 1.21–3.43 | ||||||
C + P − (5) | 2.6 | 1.15–80.5 | 17.3 | 13.85–22.6 | 192 | 105.5–579 | 493 | 372.5–565.5 | 2.19 | 1.645–3.575 | ||||||
C + P + (25) | 2.8 | 1.25–4.1 | 19.8 | 13.08–25.3 | 207 | 121.5–467 | 543 | 546.5–809.5 | 3.78† | 2.28–5.01 | ||||||
IL-6 (pg/mL) | TGF-ß1 (ng/mL) | VEGF (pg/mL) | CCL22 (pg/mL) | Treg (%) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Correlation coefficient | Correlation coefficient | Correlation coefficient | Correlation coefficient | Correlation coefficient | ||||||||||||
Age | r = 0.194 | NS | r = 0.330 | NS | r = 0.291 | NS | r = 0.397 | NS | r = − 0.102 | NS | ||||||
Brinkman index | r = − 0.034 | NS | r = 0.620 | NS | r = 0.534 | NS | r = 0.142 | NS | r = 0.173 | NS | ||||||
Number of teeth | r = 0.094 | NS | r = 0.641 | NS | r = 0.506 | NS | r = 0.876 | NS | r = − 0.024 | NS | ||||||
