Figure 2
From: Characterization of regulatory transcriptional mechanisms in hepatocyte lipotoxicity
Shared proteome remodelling in NASH and lipotoxicity. (A,B) Volcano plots showing differentially regulated proteins in (A) human liver from NASH patients (n = 4 per group) and (B) mouse hepatocytes stimulated with PAL for 24 h (n = 3 per group). Blue and red dots denote significantly down- and up-regulated proteins, respectively. (C,D) Circular plots showing the protein (purple lines) and functional (blue lines) overlap between (C) up- and (D) down-regulated proteins in human NASH and mouse hepatocyte lipotoxicity. (E,F) Gene ontology analysis showing biological processes significantly regulated in both human NASH and mouse hepatocyte lipotoxicity (E) up- and (F) down-regulated proteins.
