Table 2 Glycemic profile and outcomes: TIR of relative normoglycemia ≤ 80% vs. > 80%

From: Association between time in range of relative normoglycemia and in-hospital mortality in critically ill patients: a single-center retrospective study

Variables

Overall

N = 328

TIR ≤ 80

N = 156

TIR > 80

N = 172

P value

Glycemic profilea

The number of blood glucose measurements

14 (11, 17)

15 (12, 19)

13 (11, 16)

 < 0.001

Mean blood glucose, mg/dL

130 (114, 158)

151 (130, 187)

121 (110, 132)

 < 0.001

Coefficient of variation, %

19 (14, 27)

26 (19, 33)

15 (11, 20)

 < 0.001

Hypoglycemia (< 70 mg/dL)

24 (7.3)

15 (9.6)

9 (5.2)

0.13

Moderate hypoglycemia (≥ 40 mg/dL, < 70 mg/dL)

20 (6.1)

12 (7.7)

8 (4.7)

0.25

Severe hypoglycemia (< 40 mg/dL)

4 (1.2)

3 (1.9)

1 (0.6)

0.35

TIR of absolute normoglycemiab, %

70 (33, 91)

50 (17, 69)

86 (67, 100)

 < 0.001

TIR of absolute normoglycemiab > 80%

123 (38)

20 (13)

103 (60)

 < 0.001

Time below 70 mg/dL, %

0 (0, 0)

0 (0, 0)

0 (0, 0)

0.11

Time above 140 mg/dL, %

29 (8, 63)

50 (29, 81)

13 (0, 33)

 < 0.001

TIR of relative normoglycemiac, %

83 (65, 100)

62 (50, 73)

96 (89, 100)

 < 0.001

Time below 70% of ADAGd, %

0.0 (0.0, 9)

0.0 (0.0, 27)

0.0 (0.0, 0.0)

 < 0.001

Time above 140% of ADAGd, %

7 (0.0, 25)

25 (0.0, 40)

0 (0.0, 7)

 < 0.001

Outcomes

ICU length of stay, days

4.7 (2.8, 8.4)

5.6 (2.7, 8.2)

4.4 (2.8, 8.6)

0.73

ICU mortality

20 (6.1)

17 (11)

3 (1.7)

 < 0.001

Hospital length of stay, days

20 (13, 33)

19 (12, 33)

21 (13, 34)

0.28

Hospital mortality

35 (11)

30 (19)

5 (2.9)

 < 0.001

  1. Data are expressed as median (interquartile range) or number (%).
  2. TIR time in range, ADAG A1C-derived average glucose.
  3. aDuring the first 72 h after ICU admission or ICU stay, whichever shorter.
  4. bAbsolute normoglycemia was defined as measured blood glucose levels in the range of 70 to 140 mg/dL.
  5. cRelative normoglycemia was defined as measured blood glucose levels in the range of 70 to 140 of ADAG.
  6. d 1C-derived average glucose (mg/dL) can be obtained from the following formula: 28.7 × A1C (%) − 46.7.
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