Figure 2 | Scientific Reports

Figure 2

From: Feedback loop between hepatocyte nuclear factor 1α and endoplasmic reticulum stress mitigates liver injury by downregulating hepatocyte apoptosis

Figure 2

Knockdown of HNF1A aggravates apoptosis and reduces ATF4 and GRP78 expression during ER stress in LO2 cells. LO2 cells were pretreated with control shRNA or HNF1A shRNA for 48 h, then incubated with DMSO or TG (1.0 μmol/L) for 36 h: (A) bar chart and representative western blotting showing the alteration of HNF1α expression after HNF1A shRNA transfection; (B) bar chart representing MTS cell viability among the different experimental groups in LO2 cells; and (C) bar chart representing the relative protein expression and representative Western blotting for the different experimental groups. *p < 0.05, **p < 0.01, versus the control group (control shRNA, or control shRNA + DMSO) or TG group (control shRNA + TG).

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