Figure 3 | Scientific Reports

Figure 3

From: Feedback loop between hepatocyte nuclear factor 1α and endoplasmic reticulum stress mitigates liver injury by downregulating hepatocyte apoptosis

Figure 3

Knockdown of ATF4 aggravates apoptosis and downregulates the expression of GRP78 in TG-treated LO2 cells. LO2 cells were pretreated with control shRNA or ATF4 shRNA for 48 h and then incubated with DMSO or TG (1.0 μmol/L) for 36 h: (A) bar chart and representative Western blotting showing the alteration of ATF4 expression in different experimental; (B) bar chart representing LO2 cell viability between the different experimental groups; and (C) bar chart representing the relative protein expression and representative western blotting.**p < 0.01, versus the control (control shRNA, or control shRNA + DMSO) or TG groups (control shRNA + TG).

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