Table 2 Number of metformin prescriptions and hazard ratio on total knee replacement.
Operationalization of regular metformin use | N (matched cohort) * | Number of total knee replacements among regular metformin users (total number in cohort) | Hazard ratio (95% confidence interval) |
|---|---|---|---|
Two prescriptions or more in past year | 93,446 | 203 (425) | 0.89 (0.74–1.08) |
Three prescriptions or more in past year | 93,374 | 193 (415) | 0.85 (0.70–1.03) |
Four prescriptions or more in past year † | 93,330 | 184 (406) | 0.81 (0.67–0.98) |
Five precriptions or more in past year | 93,218 | 168 (390) | 0.74 (0.61–0.91) |
