Figure 4
From: Validation and promise of a TCR mimic antibody for cancer immunotherapy of hepatocellular carcinoma
AbTCR + co-stim receptor-positive cells can expand after infusion, reduce serum AFP levels and cause HCC tumors to regress. Each patient was assayed for vector WPRE expression by PCR analysis and serum AFP level by ELISA the day after infusion. The detection limit for the PCR is shown; each value for the clinical-grade AFP ELISA is within range of the assay. The table summarizes the correlative relationships between receptor-positive T cell expansion and AFP reduction on an infusion-by-infusion basis. Efficacy is summarized in terms of regression observed and RECIST1.1 score at the conclusion of treatment.
