Figure 6 | Scientific Reports

Figure 6

From: Immune modulation by molecularly targeted photothermal ablation in a mouse model of advanced hepatocellular carcinoma and cirrhosis

Figure 6The alternative text for this image may have been generated using AI.

Growth response of remote tumors following MTPA to orthotopic HCC tumors. (A) Remote tumors demonstrated continued growth following sham surgery (control arm, n = 15) or anti-PD-1 therapy (n = 12). However, there was inhibition of remote tumor growth following MTPA treatment to the orthotopic liver tumor (n = 12) and in the combination MTPA+anti-PD-1 therapy (n = 12), though there was no difference identified between the MTPA alone versus the combination arm. (B) Immunohistochemical analysis demonstrated a significant increase in infiltrating CD8+ T cells within the subcutaneous tumors when the orthotopic liver tumor was treated with MTPA and MTPA+anti-PD-1 therapy relative to sham surgery and anti-PD-1 therapy alone (*P < 0.05; **P < 0.01). Percentages in panel B reflect the proportion of positively stained cells within a region of interest circumscribing the tumor. Box plots reflect mean +/− standard error. The non-parametric Mann–Whitney U-test was used to evaluate differences in the proportions across treatment groups.

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