Table 1 Demographics and ocular characteristics of the study population.

From: Progression detection capabilities of circumpapillary and macular vessel density in advanced glaucomatous eyes

Parameters

POAG (n = 75)

C. Healthy (n = 33)

P-value (post hoc A vs B, A vs C, B vs C)

A. Progression (n = 17)

B. Stable (n = 58)

Age (years)

54.1 \(\pm\) 13.6

54.4 \(\pm\) 14.1

50.3 \(\pm\) 16.8

0.427

Gender, male/female

13:5

30:28

18:15

0.447a

Hypertension, n (%)

2 (11.8)

9 (15.5)

5 (15.1)

0.929a

Diabetes mellitus, n (%)

1 (5.9)

6 (10.3)

2 (6.1)

0.723a

Refractive error (diopter)

− 3.67 \(\pm\) 3.53

− 2.78 \(\pm\) 3.41

− 2.92 \(\pm\) 4.11

0.680

Axial length (mm)

25.10 \(\pm\) 1.52

25.68 \(\pm\) 2.24

25.04 \(\pm\) 1.85

0.317

CCT (\(\bf \it \bf {\varvec{\mu}}{{m}}\))

537.91 \(\pm\) 39.13

528.73 \(\pm\) 37.85

542.27 \(\pm\) 41.06

0.292

IOP at the first scanning visit (mmHg)

15.11 \(\pm\) 3.74

15.52 \(\pm\) 3.56

16.54 \(\pm\) 4.99

0.407

Number of medications at the first scanning visit

2.2 \(\pm\) 0.7

1.2 \(\pm\) 1.0

0.0 \(\pm\) 0.0

 < 0.001 (< 0.001, 0.002, < 0.001)b

VF measurement (dB)

Baseline VF MD

− 16.62 \(\pm\) 6.31

− 16.32 \(\pm\) 4.64

− 0.69 \(\pm\) 1.23

 < 0.001 (0.966, < 0.001, < 0.001)b

Final VF MD

− 19.22 \(\pm\) 5.98

− 16.51 \(\pm\) 4.42

− 0.66 \(\pm\) 1.34

 < 0.001 (0.048, < 0.001, < 0.001)b

cpRNFL measurement (\(\bf \bf \it {\varvec{\mu}}\mathbf{{m}}\))

Baseline average thickness

54.9 \(\pm\) 13.7

59.4 \(\pm\) 12.9

91.4 \(\pm\) 13.6

 < 0.001 (0.462, < 0.001, < 0.001)b

Final average thickness

54.2 \(\pm\) 14.2

59.1 \(\pm\) 13.2

89.4 \(\pm\) 12.0

 < 0.001 (0.377, < 0.001, < 0.001)b

Macular GCC measurement (\(\bf \bf \it {\varvec{\mu}}\mathbf{{m}}\))

Baseline average thickness

67.5 \(\pm\) 9.9

66.7 \(\pm\) 8.8

91.1 \(\pm\) 11.0

 < 0.001 (0.961, < 0.001, < 0.001)b

Final average thickness

67.6 \(\pm\) 9.5

66.1 \(\pm\) 9.6

91.0 \(\pm\) 10.9

 < 0.001 (0.906, < 0.001, < 0.001)b

OCTA vessel density measurement (%)

Baseline average cpVD

37.4 \(\pm\) 9.3

37.1 \(\pm\) 6.0

48.2 \(\pm\) 5.3

 < 0.001 (0.977, < 0.001, < 0.001)b

Final average cpVD

32.6 \(\pm\) 6.4

35.3 \(\pm\) 6.6

47.6 \(\pm\) 6.0

 < 0.001 (0.290, < 0.001, < 0.001)b

Baseline average mVD

37.7 \(\pm\) 3.8

37.1 \(\pm\) 4.1

45.7 \(\pm\) 5.2

 < 0.001 (0.863, < 0.001, < 0.001)b

Final average mVD

35.6 \(\pm\) 3.9

36.1 \(\pm\) 4.5

45.0 \(\pm\) 4.9

 < 0.001 (0.908, < 0.001, < 0.001)b

  1. CCT central corneal thickness, cpRNFL circumpapillary retinal nerve fiber layer, cpVD circumpapillary vessel density, dB decibels, GCC ganglion cell complex, IOP intraocular pressure, MD mean deviation, mVD macular vessel density, n number, OCTA optical coherence tomography angiography, VF visual field.
  2. Boldface values indicates statistical significance.
  3. aFisher exact test.
  4. bone-way analysis of variance with the Tukey’s post hoc test.
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