Figure 4
IL-12 treatment of B-ALL bearing mice creates an immunostimulatory soluble milieu in the bone marrow. (A) Luminex assay was used to measure cytokines and chemokines levels in the bone marrow of control and rIL-12 treated WT mice at day 7 (n = 6 mice/group). The heatmap shows concentrations relative to the median with supervised hierarchical clustering by treatment condition. (B) Cytokines with altered concentrations attributed to leukemia. (C) Cytokines/chemokines with altered concentrations due to leukemia and normalized with IL-12. (D) Cytokines/chemokines altered due to IL-12. (*P < 0.05; **P < 0.01; ****P < 0.0001, ANOVA with Tukey multiple comparisons test).
