Table 7 The univariate and multivariate analysis for the PFI (TCGA-PAAD).

From: Pancreatic adenocarcinoma associated immune-gene signature as a novo risk factor for clinical prognosis prediction in hepatocellular carcinoma

Characteristics

Total (N)

Univariate analysis

Multivariate analysis

Hazard ratio (95% CI)

P value*

Hazard ratio (95% CI)

P value*

T stage

T1&T2

31

Reference

   

T3&T4

145

2.414 (1.309–4.452)

0.005

1.536 (0.605–3.903)

0.367

N stage

N0

50

Reference

   

N1

123

1.735 (1.113–2.705)

0.015

1.613 (0.853–3.048)

0.141

M stage

M0

79

Reference

   

M1

5

0.837 (0.300–2.336)

0.734

  

Pathologic stage

Stage I

21

Reference

   

Stage II

146

2.966 (1.353–6.501)

0.007

0.572 (0.152–2.162)

0.410

Stage III&IV

8

2.965 (0.976–9.014)

0.055

0.494 (0.101–2.422)

0.384

Gender

Female

80

Reference

   

Male

98

0.968 (0.658–1.423)

0.867

  

Age

 ≤ 65

93

Reference

   

 > 65

85

1.256 (0.848–1.861)

0.256

  

Radiation therapy

No

118

Reference

   

Yes

45

0.744 (0.474–1.168)

0.199

  

Primary therapy outcome

PD&SD

58

Reference

   

PR&CR

81

0.336 (0.216–0.524)

 < 0.001

0.454 (0.278–0.743)

0.002

Residual tumor

R0

107

Reference

   

R1&2

57

2.253 (1.494–3.398)

 < 0.001

2.042 (1.239–3.363)

0.005

Histologic grade

G1

31

Reference

 

NA

 

G2

95

1.740 (0.956–3.170)

0.070

0.774 (0.355–1.685)

0.518

G3&G4

50

2.570 (1.361–4.853)

0.004

1.149 (0.500–2.641)

0.743

Anatomic neoplasm subdivision

Head of Pancreas

138

Reference

   

Other

40

0.495 (0.299–0.820)

0.006

0.637 (0.335–1.210)

0.168

Smoker

No

65

Reference

   

Yes

79

1.048 (0.683–1.606)

0.831

  

Alcohol history

No

65

Reference

   

Yes

101

1.217 (0.799–1.851)

0.360

  

History of diabetes

No

108

Reference

   

Yes

38

0.783 (0.460–1.333)

0.368

  

History of chronic pancreatitis

No

128

Reference

   

Yes

13

0.885 (0.426–1.840)

0.744

  

Family history of cancer

No

47

Reference

   

Yes

63

0.955 (0.574–1.590)

0.860

  

Model

 

178

2.718 (1.881–3.929)

 < 0.001

2.783 (1.670–4.639)

 < 0.001

  1. PFI progress free interval, CI confidence interval, NA reference group or could not be evaluated.
  2. *Compared with each group (log-rank test or Omnibus test for univariate, Cox regression analysis with adjusted hazard for multivariate). p < 0.05 means statistically significant (highlighted in bold).
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