Figure 1 | Scientific Reports

Figure 1

From: A rationally identified panel of microRNAs targets multiple oncogenic pathways to enhance chemotherapeutic effects in glioblastoma models

Figure 1

Differentially expressed miRNAs selected for applications in GBM treatment and their target genes expression. (a) Two datasets from GEO and one from TCGA were selected for this study. Commonly dysregulated miRNAs were selected by applying two selection criteria, and the results identified 24 differentially expressed miRNAs in GBM. Target genes for each miRNA were identified. Gene expression in GBM vs. normal brain tissue, survival analysis and correlation between the expression of miRNAs and their target genes were investigated for each target gene. The candidate miRNAs were distributed in four therapeutic pathways based on the identified target genes (b) Heatmap of the selected miRNA expressions in patient GBM tissues compared to normal. Values are normalized to the average expressions of normal brain tissue for each miRNA. Heatmap colors represent relative miRNA expression as shown in the color key. (c) The target genes of identified miRNAs selected for this study. Genes are color coded based on the therapeutic pathways. (d) Final six selected miRNAs and their representative target genes expressions in GBM and normal tissues. The target genes expressions are shown from GEPIA database. Significance levels are shown in the right margins: **adjusted p < 0.01; ****adjusted p < 0.0001. Genes and miRNAs (except SMAD7) were significant at |log2FC|> 1.

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