Figure 2 | Scientific Reports

Figure 2

From: A rationally identified panel of microRNAs targets multiple oncogenic pathways to enhance chemotherapeutic effects in glioblastoma models

Figure 2

Survival curves of the target genes for each of the six selected miRNAs, and correlation of each target genes with respective miRNA expression. Correlation between the target gene and miRNA were studied in four different GBM subtypes: mesenchymal, neural, proneural, and classical. (a) miRNA-138/CDK6-involved in proliferation. (b) miRNA-139/ZEB1-involved in migration and invasiveness. (c) miRNA-203/FGFR1-involved in mesenchymal transition. (d) miRNA-218/STAT3-involved in cytokine signaling. (e) miRNA-490/TGIF2-involved in EMT. (f) miRNA-21/SMAD7-involved in invasion and drug resistance. In survival analysis plots, p indicates the P-value. Low and High refer to top and bottom 20% of expressions. In correlation plots, S- indicates the slope of the regression line fitted on the expression data. Complete plots of all target genes that were found for each miRNA are shown in Supplementary Fig. S1 (Supplemental).

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