Figure 6 | Scientific Reports

Figure 6

From: A rationally identified panel of microRNAs targets multiple oncogenic pathways to enhance chemotherapeutic effects in glioblastoma models

Figure 6

In vivo evaluation of the delivery and chemosensitizing effect of the panel of miRNAs (miR-138, miR-139, miR-218, miR-490, and Amir-21) followed by TMZ in U87-MG xenografts in mice. (a) Schematic of in vivo workflow. (b) Survival curves of the mice at different treatment group (number of tumors, N = 6–8 per group). (c) Tumor weight at the terminal point for mice in different treatment groups. The insert shows the last two groups. (d) Estimated tumor volume in different treatment groups. Since some of the mice were sacrificed earlier, all the curves except miRNA plus TMZ were estimated by fitting an exponential growth model to data. (e) Biodistribution of miRNA-138, miRNA-139, miRNA-218, miRNA-490, and antimiRNA-21 in tumors of mice in different treatment groups. (f) Biodistribution of antimiRNA-21 in different organs of mice in different treatment groups.

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