Figure 1
Construction and validation of the mRNA model. (A) Selection of mRNAs with HR > 1 and up-regulation, and mRNAs with HR < 1 and down-regulation in HCC. (B) LASSO coefficients of the six key mRNAs. The dotted vertical line is drawn at the λ value chosen by the minimum criteria. L1 Norm represents the summation of absolute nonzero coefficients at each λ. Y-axis represents the values of nonzero coefficients at each λ. (C) The evaluation of the mRNA model via the ROC curve and C-index in the TCGA training set. (D) Kaplan–Meier survival analysis of the different risk groups stratified with the trisection of the mRNA risk score in the TCGA training set. (E) The verification of the mRNA model via the ROC curve and C-index in the TCGA test set. (F) The verification of the mRNA model with Kaplan–Meier survival analysis in the TCGA test set. (G) The external validation of the mRNA model via the ROC curve and C-index in the LIRI-JP dataset. (H) The external validation of the mRNA model with Kaplan–Meier survival analysis in the LIRI-JP dataset. HCC hepatocellular carcinoma, TCGA The Genome Cancer Atlas, C-index Harrell’s concordance index, ROC receiver operating characteristic, AUC area under the curve, LASSO least absolute shrinkage and selection operator, HR hazard rate ratio.
