Table 3 Synthesis of spiro-2-amino-4H-pryans37.
| ||||||
|---|---|---|---|---|---|---|
Entry | Product | Time (min) | Yield % | TOF | M.p./ °C Obs | M.p. °C/Lit |
1 |
| 12 | 96 | 320 | 295–298 | 298–299 |
2 |
| 15 | 96 | 256 | 251–254 | 253–255 |
3 |
| 8 | 94 | 482 | 290–293 | 290–292 |
4 |
| 10 | 92 | 368 | 255–258 | 256–258 |
5 |
| 16 | 92 | 230 | 299–302 | > 300 |
6 |
| 20 | 91 | 182 | 253–254 | 251–253 |
7 |
| 22 | 90 | 163 | 241–243 | 240–242 |
8 |
| 25 | 90 | 144 | 261–263 | 262–264 |
9 |
| 20 | 91 | 182 | 270–272 | 273–275 |
10 |
| 25 | 90 | 144 | 208–211 | 207–209 |
11 |
| 20 | 94 | 188 | 236–239 | 236–237 |
12 |
| 22 | 90 | 163 | 232–235 | 235–236 |
13 |
| 22 | 91 | 165 | 286–287 | 285–286 |
14 |
| 21 | 92 | 175 | 280–282 | 280–281 |
15 |
| 22 | 89 | 164 | 239–242 | 242–243 |
16 |
| 16 | 91 | 233 | 245–248 | 245–247 |
17 |
| 10 | 95 | 395 | 269–273 | 268–270 |
18 |
| 14 | 92 | 262 | 257–260 | 259–262 |
19 |
| 18 | 93 | 206 | > 300 | > 300 |
20 |
| 24 | 88 | 146 | 195–198 | 194–196 |
21 |
| 26 | 91 | 141 | > 300 | > 300 |
22 |
| 21 | 90 | 171 | > 300 | > 300 |
23 |
| 25 | 91 | 144 | 256–258 | 258–260 |
24 |
| 22 | 94 | 174 | 195–198 | 193–196 |
25 |
| 25 | 95 | 151 | 297–299 | 298–299 |
26 |
| 24 | 93 | 155 | 248–249 | 247–248 |
