Table 3 Hazard ratios and C-statistics of various models for predicting end-stage kidney disease (ESKD) as evaluated by the Cox proportional hazard model.
From: A simplified prediction model for end-stage kidney disease in patients with diabetes
Model | Explanation variables | Hazard ratio | 95% CI Lower–upper | P value | C-statistic (SD) |
|---|---|---|---|---|---|
1 | eGFR, per 5 mL min−1 [1.73 m]−2 | 0.690 | 0.663–0.717 | < 0.001 | 0.736 (0.091) |
2 | eGFR, per 5 mL min−1 [1.73 m]−2 Proteinuria, positive | 0.754 6.679 | 0.724–0.785 4.443–10.038 | < 0.001 < 0.001 | 0.806 (0.090) |
3 | eGFR, per 5 mL min−1 [1.73 m]−2 Proteinuria, positive HbA1c, per 1% | 0.745 6.755 1.493 | 0.716–0.776 4.421–10.321 1.379–1.615 | < 0.001 < 0.001 < 0.001 | 0.841 (0.068) |
4.1 | eGFR, per 5 mL min−1 [1.73 m]−2 Proteinuria, positive HbA1c, per 1% Serum albumin, per 3 mg/dL | 0.763 4.106 1.460 0.581 | 0.733–0.795 2.610–6.458 1.349–1.579 0.507–0.665 | < 0.001 < 0.001 < 0.001 < 0.001 | 0.852 (0.070) |
4.2 | eGFR, per 5 mL min−1 [1.73 m]−2 Proteinuria, positive HbA1c, per 1% Serum bilirubin, per 0.1 mg/dL | 0.766 6.199 1.443 0.797 | 0.736–0.798 4.033–9.528 1.336–1.560 0.732–0.867 | < 0.001 < 0.001 < 0.001 < 0.001 | 0.881 (0.061) |
5 | eGFR, per 5 mL min−1 [1.73 m]−2 Proteinuria, positive HbA1c, per 1% Serum albumin, per 3 mg/dL Serum bilirubin, per 0.1 mg/dL | 0.773 4.019 1.432 0.626 0.865 | 0.742–0.805 2.540–6.361 1.325–1.548 0.543–0.722 0.797–0.938 | < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 | 0.895 (0.065) |
6 | All variables | 0.905 (0.050) |
