Figure 4
Interactions between SPH1118 and the ligands. Red, blue, and yellow represent oxygen, nitrogen, and sulfur atoms, respectively in (a–e). (a) Residues interacting with GalUA, MES, and ΔtriGalUA via hydrogen bonds and C–C contacts shown in stereo view. Line models show the side chains of the residues interacting with each ligand. Stick models show each ligand (GalUA, MES, and ΔtriGalUA). Cyan, SPH1118/GalUA; magenta, SPH1118/2 × MES; orange, SPH1118/ΔtriGalUA. (b) Omit maps of GalUA, MES, and ΔtriGalUA. Electron density maps (Fo–Fc) of each ligand are shown in green mesh contoured with 3.0 σ. (c) Residues interacting with GalUA. Dotted lines represent hydrogen bonds. Cyan represents carbon atom. (d) Residues interacting with MES. Dotted lines represent hydrogen bonds. Magenta represents carbon atom. (e) Residues interacting with ΔtriGalUA. Dotted lines represent hydrogen bonds. Orange represents carbon atom.
