Figure 2 | Scientific Reports

Figure 2

From: Reduced dynamic loads due to hip dislocation induce acetabular cartilage degeneration by IL-6 and MMP3 via the STAT3/periostin/NF-κB axis

Figure 2The alternative text for this image may have been generated using AI.

RNA-sequencing analysis of the acetabular cartilage of 3-week-old DA-DDH rats. (a) Volcano plot for RNA-sequencing data obtained from the acetabular cartilage of 3-week-old rats. Control and DA-DDH groups involved bilateral acetabulum pooled from 4 and 5 rats, respectively. Black dots indicate significantly (P < 0.05) and differentially expressed genes in the DA-DDH rats whose expression was modulated by more than twofold. The table summarizes the number and percentage of differentially expressed (upper row) and significantly upregulated and downregulated expressed genes (lower row). (b) Gene Ontology (GO) analyses were performed using the DAVID bioinformatics resource. Functional annotation clustering of keywords among the GO terms for 81 genes that were significantly differentially expressed between the control and DA-DDH groups (P < 0.05). (c) The enriched GO Biological Process in 21 significantly upregulated and 60 significantly downregulated genes in DA-DDH rats is illustrated by − log10(P-value). (d) Genes related to cell adhesion and chondrogenesis were detected among 15 extracellular region/ECM-related genes in DA-DDH rats. The table shows the expression of cell adhesion and chondrogenic marker genes in the extracellular region/ECM-related genes.

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