Figure 6 | Scientific Reports

Figure 6

From: Reduced dynamic loads due to hip dislocation induce acetabular cartilage degeneration by IL-6 and MMP3 via the STAT3/periostin/NF-κB axis

Figure 6

IL-6 accelerated STAT3-Postn-NF-κB signaling. (a) Western blot results for p-STAT3, STAT3, p-p65, and p65 expression in rat primary chondrocytes treated with recombinant IL-6 (rIL6; 50 ng/ml) for 2 h. (b) Real-time qPCR results for Postn and Mmp3 expression in rat primary chondrocytes treated with rIL-6 (0, 50, 100 ng/ml) for 24 h (n = 6 per group). (c) Real-time qPCR results for Postn expression in rat primary chondrocytes treated with rIL-6 (50 ng/ml) alone or together with Stattic for 24 h (n = 6 per group). (d) Real-time qPCR results for Mmp3 expression in rat primary chondrocytes treated with rIL-6 (50 ng/ml) alone or together with Stattic or BAY11-7082 for 24 h (n = 6 per group). The Kruskal–Wallis test was used for multiple comparisons. The Mann–Whitney U test was used for comparisons between two groups. Values indicate the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.

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