Figure 7 | Scientific Reports

Figure 7

From: Reduced dynamic loads due to hip dislocation induce acetabular cartilage degeneration by IL-6 and MMP3 via the STAT3/periostin/NF-κB axis

Figure 7

Postn deficiency suppressed cartilage degeneration in the acetabulum of DA-DDH mice. (a) SO staining, in situ hybridization (Col2a1, Col1a1, and Postn), and immunostaining (Postn) of the anterior wall of the acetabulum in 6-week-old mice. The white dotted line in the Col2a1 in situ hybridization indicates the joint line of the acetabulum. The black and white arrowheads indicate a fibrous change of cartilage, downregulated expression of Col2a1, upregulated expression of Col1a1, and Postn positive cells. Scale bar: SO staining; 100 μm, in situ hybridization; 200 μm, immunostaining; 50 μm. (b) Immunostaining for p-p65, IL-6, and Mmp3 expression of the anterior wall of the acetabulum in the 6-week-old mice. The black arrowheads indicate p-p65-, IL-6-, and Mmp3-positive cells. Scale bar: 50 μm. (c) Immunostaining for p-STAT3 expression in the anterior wall of the acetabulum in 6-week-old mice. Scale bar: 50 μm.

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