Figure 3
Sex-specific sensitivity or specificity for detecting anatomically defined left ventricular hypertrophy (LVH) in the respective cohorts. In both the Imaging-LVH and Clinical-Consecutive cohorts, an increased QRS-T angle had a higher sensitivity for LVH than all other ECG measures (p < 0.05 for all). Among females in the Healthy-Validation cohort, the specificity of the QRS-T angle for LVH was higher than that of QRS duration (p < 0.001), lower than Cornell product (p < 0.05), and did not differ significantly from that of the other measures (p > 0.05 for all). Among males in the Healthy-Validation cohort, the specificity of the QRS-T angle for LVH was higher than that of QRS duration (p < 0.001), lower than Cornell voltage and Cornell voltage product (p < 0.05 for both), and did not differ significantly from Sokolow-Lyon index (p = 0.12). In the Clinical-Consecutive cohort, the QRS-T angle had a lower specificity than the other ECG measures (p < 0.05 for all) despite its excellent specificity in the Healthy-Validation cohort, suggesting possible electrical identification of subclinical disease in patients who do not yet fulfill imaging criteria for LVH.
