Table 1 Prevalent migraine in patients with diabetes according to level of diabetic retinopathy and their corresponding age- and gender-matched controls.

Level of DR	Patients with diabetes			Age- and gender matched controls			OR (95% CI)
Level of DR	Patients with migraine	Total number of patients	Prevalence of migraine (%)	Patients with migraine	Total number of patients	Prevalence of migraine (%)	Crude	Age and gender	Multivariable
All	12,512	205,970	6.1	65,224	1,003,170	6.5	0.93 (0.91;0.95)	0.93 (0.91;0.95)	0.83 (0.81;0.85)
0	10,914	171,795	6.3	54,975	836,865	6.6	0.96 (0.95;0.99)	0.97 (0.94;0.99)	0.87 (0.85;0.89)
1–4	1598	34,175	4.7	10,249	166,305	6.2	0.75 (0.71;0.79)	0.74 (0.70;0.79)	0.67 (0.63;0.71)
1	1045	21,131	4.9	6342	102,788	6.2	0.79 (0.74;0.85)	0.79 (0.73;0.84)	0.70 (0.65;0.76)
2	279	6594	4.2	1853	32,095	5.8	0.72 (0.63;0.82)	0.72 (0.63;0.82)	0.68 (0.59;0.78)
3	44	1162	3.8	350	5681	6.2	0.60 (0.44;0.83)	0.59 (0.43;0.82)	0.51 (0.35;0.73)
4	230	5288	4.3	1704	25,741	6.6	0.64 (0.56;0.74)	0.64 (0.55;0.73)	0.54 (0.46;0.64)

Odds ratio (OR) with 95% confidence interval (CI) for prevalent migraine for patients with diabetes mellitus screened for diabetic retinopathy (DR) (cases) compared to age- and gender-matched controls (1:5) according to level of DR for cases at the time of the first registration in the Danish Registry of Diabetic Retinopathy for cases.
CI confidence interval.
Level of DR given by the worse eye.
Multivariable model adjusted for sex, age, marital status, use of lipid lowering drugs and Charlson comorbidity index: myocardial infarct, congestive heart failure, cerebrovascular disease, chronic pulmonary disease, connective tissue disease/rheumatologic disease, ulcer disease, mild liver disease, hemiplegia/hemiplegia or paraplegia, any malignancy (including leukemia and lymphoma), moderate-severe liver disease, solid metastatic tumor, and acquired immunodeficiency syndrome.

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