Table 3 Incident migraine in patients with diabetes according to level of diabetic retinopathy and their corresponding age- and gender-matched controls.

Level of DR	Patients with diabetes		Age- and gender matched controls		HR (95% CI)
Level of DR	Events	Person-years	Events	Person-years	Crude	Age and gender	Multivariable
All	784	623,261	4716	3,015,920	0.80 (0.75;0.87)	0.81 (0.75;0.87)	0.76 (0.70;0.82)
0	617	501,244	3619	2,419,531	0.82 (0.76;0.90)	0.83 (0.76;0.90)	0.79 (0.71;0.87)
1–4	167	122,016	1097	596,389	0.74 (0.63;0.88)	0.74 (0.63;0.87)	0.66 (0.55;0.80)
1	99	74,975	655	363,764	0.73 (0.59;0.90)	0.73 (0.59;0.90)	0.67 (0.53;0.85)
2	35	23,490	215	115,471	0.80 (0.56;1.14)	0.78 (0.55;1.12)	0.66 (0.44;0.99)
3	10	4056	41	20,116	1.20 (0.61;2.41)	1.18 (0.59;2.36)	1.20 (0.54;2.64)
4	23	19,494	186	97,038	0.61 (0.40;0.95)	0.60 (0.39;0.92)	0.53 (0.32–0.88)

Hazard ratio (HR) with 95% confidence interval (CI) for 5-year incident migraine after index date for patients with diabetes mellitus screened for diabetic retinopathy (DR) and age- and gender-matched controls according to level of DR for cases.
CI confidence interval.
Level of DR given by the worse eye.
Multivariable model adjusted adjusted for sex, age, marital status, use of lipid lowering drugs and Charlson comorbidity index: myocardial infarct, congestive heart failure, cerebrovascular disease, chronic pulmonary disease, connective tissue disease/rheumatologic disease, ulcer disease, mild liver disease, hemiplegia/hemiplegia or paraplegia, any malignancy (including leukemia and lymphoma), moderate-severe liver disease, solid metastatic tumor, and acquired immunodeficiency syndrome.

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