Figure 7

Relative sensitivity of the simulated Kr value at the 5th minute of HD (priming saline discarded) to the values of selected model parameters (only the parameters with the relative sensitivity above ± 0.5 are shown). Symbol meanings: αUP—fraction of LpS attributed to large pores, DU—urea clearance (used also for all other solutes in the model, except for creatinine and bicarbonate), Upl—pre-dialysis plasma urea level, exTBW and icTBW—fractions of normal total body water attributed to extravascular extracellular space and extravascular intracellular space, respectively, rSP—small pore radius, TP—pre-dialysis total protein level, Fpl—normal plasma water fraction, Clpl—pre-dialysis plasma chloride level, αDCl—Gibbs-Donnan coefficient for chloride across the dialyzer membrane, Cldi—chloride concentration in the dialysis fluid, bTWB—fraction of normal total body water attributed to blood, TBW—total body water, CO—normal cardiac output, LpS—whole-body capillary hydraulic conductivity, GcR—low-pressure (cardiopulmonary) gain of the baroreflex mechanism controlling vascular resistance, pVsv—normal fraction of total blood volume attributed to small veins and venules. For figure clarity, the following parameters (sensitivities) were not shown: Napl—pre-dialysis plasma sodium level (−8.7), Nadi—sodium concentration in the dialysis fluid (9.0), Fpl0—pre-dialysis plasma water fraction (12.4), αDNa—the Gibbs-Donnan coefficient for sodium across the dialyzer membrane (9.4).