Figure 5
From: Expression of antioxidant enzymes in lesions of multiple sclerosis and its models
Spatial transcriptomic analysis of antioxidant protein expression in chronic active MS brain lesions. (A) Representative microscopy image of post-mortem MS brain tissue labeled with hematoxylin and eosin. This is a white matter region of the frontal lobe. (B) Spatial demarcation of the MS tissue into anatomical regions (NAWM, inactive core, and active edge) based on their expression of MBP and cellularity. (C) Heatmap showing the expression of genes across control WM and the segmented regions of MS tissue. (D) Violin plot showing the combined sum of expression of SOD1, HMOX-1, PRDX5, and GPX4 in the different anatomical regions of the MS tissue. Data representative from 2 healthy control and 2 MS samples.
